Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

Purpose To provide a practical overview of the management of the potential organ donor in
the intensive care unit. Methods Seven areas of donor management were considered for this …

Background Hemodynamic instability and myocardial dysfunction are major factors
preventing the transplantation of hearts from organ donors after brain death. Intravenous …

The proposed donor heart selection guidelines provide evidence-based and expert-
consensus recommendations for the selection of donor hearts following brain death. These …

In this review, we discuss the characteristics, pathophysiology, and therapeutic implications
of the euthyroid sick syndrome. Multiple mechanisms have been identified to contribute to …

We discuss what therapeutic regimen might be acceptable/successful in the first clinical trial
of genetically engineered pig kidney or heart transplantation. As regimens based on a …

Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and
infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with …

Background: Intravenous (IV) iron preparations are widely used in the treatment of anemia in
patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing …

The importance of the complement system in renal ischemia-reperfusion injury and acute
rejection is widely recognized, however its contribution to the pathogenesis of tissue …

Thyroid hormone levels are reduced in cardiovascular diseases and this phenomenon is
associated with worse outcomes. It is unclear whether the changes in thyroid hormone …