Degeneration of the dopamine (DA) neurons of the substantia nigra pars compacta and the
resulting loss of nerve terminals accompanied by DA deficiency in the striatum are …

Animal models are an important aid in experimental medical science because they enable
one to study the pathogenetic mechanisms and the therapeutic principles of treating the …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

Parkinson's disease is thought to be caused by some unknown endogenous or exogenous
factors interacting with genetic dispositions. 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …

Biochemical studies on postmortem brains of patients with Parkinson's disease (PD) have
greatly contributed to our understanding of the molecular pathogenesis of this disease. The …

Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the
oxidative deamination of monoamine neurotaransmitters such as dopamine (DA) …

Aberrant oxidative pathways of catecholamine neurotransmitters, ie dopamine and
norepinephrine, are an important biochemical correlate of catecholaminergic neuron loss in …

Monoamine oxidase (MAO) is an enzyme that oxidizes various physiologically and
pathologically important monoamine neurotransmitters and hormones such as dopamine …

There is consensus that amelioration of the motor symptoms of Parkinson's disease is most
effective with l-DOPA (levodopa). However, this necessary therapeutic step is biased by an …

Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the
number decline by aging at 5–10% per decade. Enzymatic and non-enzymatic oxidation of …