Aortic aneurysms: current pathogenesis and therapeutic targets
MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology
D Domagała, K Data, H Szyller, M Farzaneh… - Cells, 2024 - mdpi.com
A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm,
which is characterized by a significant bulge on the vessel surface that may have …
which is characterized by a significant bulge on the vessel surface that may have …
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, a unique
subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is …
subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is …
The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms
An abdominal aortic aneurysm (AAA) is a pathological widening of the aortic wall
characterized by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and …
characterized by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and …
Development of pharmacotherapies for abdominal aortic aneurysms
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …
Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations
BACKGROUND: Smooth muscle cells (SMCs), which make up the medial layer of arteries,
are key cell types involved in cardiovascular disease, the leading cause of mortality and …
are key cell types involved in cardiovascular disease, the leading cause of mortality and …
A Multi‐Bioactive Nanomicelle‐Based “One Stone for Multiple Birds” Strategy for Precision Therapy of Abdominal Aortic Aneurysms
W Lin, K Hu, C Li, W Pu, X Yan, H Chen… - Advanced …, 2022 - Wiley Online Library
Abdominal aortic aneurysm (AAA) remains a lethal aortic disease in the elderly. Currently,
no effective drugs can be clinically applied to prevent the development of AAA. Herein, a …
no effective drugs can be clinically applied to prevent the development of AAA. Herein, a …
Integrating oculomics with genomics reveals imaging biomarkers for preventive and personalized prediction of arterial aneurysms
Objective Arterial aneurysms are life-threatening but usually asymptomatic before requiring
hospitalization. Oculomics of retinal vascular features (RVFs) extracted from retinal fundus …
hospitalization. Oculomics of retinal vascular features (RVFs) extracted from retinal fundus …
Molecular mechanisms in genetic aortopathy–signaling pathways and potential interventions
CX Dong, C Malecki, E Robertson, B Hambly… - International Journal of …, 2023 - mdpi.com
Thoracic aortic disease affects people of all ages and the majority of those aged< 60 years
have an underlying genetic cause. There is presently no effective medical therapy for …
have an underlying genetic cause. There is presently no effective medical therapy for …