Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease
D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …
cause of progressive dementia in senior adults. It is characterized by memory loss and …
The effects of essential oils and terpenes in relation to their routes of intake and application
S Koyama, T Heinbockel - International journal of molecular sciences, 2020 - mdpi.com
Essential oils have been used in multiple ways, ie, inhaling, topically applying on the skin,
and drinking. Thus, there are three major routes of intake or application involved: the …
and drinking. Thus, there are three major routes of intake or application involved: the …
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes
Brown adipose tissue (BAT) and beige fat function in energy expenditure in part due to their
role in thermoregulation, making these tissues attractive targets for treating obesity and …
role in thermoregulation, making these tissues attractive targets for treating obesity and …
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …
Modulation of TRPV1 channel function by natural products in the treatment of pain
MA Abbas - Chemico-biological interactions, 2020 - Elsevier
The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
[HTML][HTML] TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy
A Fernández-Carvajal… - Frontiers in Molecular …, 2022 - frontiersin.org
Chronic pain and pruritus are highly disabling pathologies that still lack appropriate
therapeutic intervention. At cellular level the transduction and transmission of pain and …
therapeutic intervention. At cellular level the transduction and transmission of pain and …
[HTML][HTML] The promise of niacin in neurology
E Wuerch, GR Urgoiti, VW Yong - Neurotherapeutics, 2023 - Elsevier
Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of
statins, niacin was commonly used to counter dyslipidemia. Recent evidence has posited …
statins, niacin was commonly used to counter dyslipidemia. Recent evidence has posited …
Anticancer activity of region B capsaicin analogs
KC Brown, KJ Modi, RS Light, AJ Cox… - Journal of Medicinal …, 2023 - ACS Publications
The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent
flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses …
flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses …
Molecular characterization of capsaicin binding interactions with ovalbumin and casein
Capsaicin (CAP) rich diets may help with a variety of human pathophysiological conditions;
however, CAP administration is difficult due to its high pungency and limited water solubility …
however, CAP administration is difficult due to its high pungency and limited water solubility …
TRPV1 ion channel: Structural features, activity modulators, and therapeutic potential
IN Gladkikh, OV Sintsova, EV Leychenko… - Biochemistry (Moscow …, 2021 - Springer
Although TRPV1 ion channel has been attracting researchers' attention for many years, its
functions in animal organisms, the principles of regulation, and the involvement in …
functions in animal organisms, the principles of regulation, and the involvement in …