CRISPR–cas9: A history of its discovery and ethical considerations of its use in genome editing

I Gostimskaya - Biochemistry (Moscow), 2022 - Springer
The development of a method for genome editing based on CRISPR–Cas9 technology was
awarded The Nobel Prize in Chemistry in 2020, less than a decade after the discovery of all …

Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research

ZH Li, J Wang, JP Xu, J Wang, X Yang - Military Medical Research, 2023 - Springer
The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …

Programmable RNA sensing for cell monitoring and manipulation

Y Qian, J Li, S Zhao, EA Matthews, M Adoff, W Zhong… - Nature, 2022 - nature.com
RNA is a central and universal mediator of genetic information underlying the diversity of cell
types and cell states, which together shape tissue organization and organismal function …

Public views on polygenic screening of embryos

MN Meyer, T Tan, DJ Benjamin, D Laibson, P Turley - Science, 2023 - science.org
For decades, people have used genetic information to exercise control over the kinds of
children they will have. These technologies have largely targeted chromosomal and …

Beyond safety: mapping the ethical debate on heritable genome editing interventions

M Almeida, R Ranisch - Humanities and Social Sciences …, 2022 - nature.com
Genetic engineering has provided humans the ability to transform organisms by direct
manipulation of genomes within a broad range of applications including agriculture (eg, GM …

CRISPR/Cas9: regulations and challenges for law enforcement to combat its dual-use

AK Wani, N Akhtar, S Shukla - Forensic science international, 2022 - Elsevier
For many years, scientists have aspired to edit any DNA segment of living organisms
precisely, and with the discovery of CRISPR/Cas9, they have moved closer to achieving …

Handling ethics dumping and neo-colonial research: from the laboratory to the academic literature

JA Teixeira da Silva - Journal of bioethical inquiry, 2022 - Springer
This paper explores that the topic of ethics dumping (ED), its causes and potential remedies.
In ED, the weaknesses or gaps in ethics policies and systems of lower income countries are …

CRISPR/Cas9 technology: applications in oocytes and early embryos

Y Zhang, T Yin, L Zhou - Journal of Translational Medicine, 2023 - Springer
CRISPR/Cas9, a highly versatile genome-editing tool, has garnered significant attention in
recent years. Despite the unique characteristics of oocytes and early embryos compared to …

Heritable human genome editing: research progress, ethical considerations, and hurdles to clinical practice

J Turocy, EY Adashi, D Egli - Cell, 2021 - cell.com
Our genome at conception determines much of our health as an adult. Most human diseases
have a heritable component and thus may be preventable through heritable genome editing …

The promise and challenges of genomics‐informed periodontal disease diagnoses

L Nibali, K Divaris, EMC Lu - Periodontology 2000, 2024 - Wiley Online Library
Recent advances in human genomics and the advent of molecular medicine have
catapulted our ability to characterize human and health and disease. Scientists and …