Blood-based biomarkers for hepatocellular carcinoma screening: Approaching the end of the ultrasound era?

ND Parikh, N Tayob, AG Singal - Journal of hepatology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, in
part because of inadequate early detection strategies. Current recommendations for …

Updating the clinical application of blood biomarkers and their algorithms in the diagnosis and surveillance of hepatocellular carcinoma: a critical review

E Shahini, G Pasculli, AG Solimando, C Tiribelli… - International Journal of …, 2023 - mdpi.com
The most common primary liver cancer is hepatocellular carcinoma (HCC), and its mortality
rate is increasing globally. The overall 5-year survival of patients with liver cancer is …

Discovery of core-fucosylated glycopeptides as diagnostic biomarkers for early HCC in patients with NASH cirrhosis using LC-HCD-PRM-MS/MS

Y Tan, J Zhu, CD Gutierrez Reyes, Y Lin, Z Tan… - ACS …, 2023 - ACS Publications
Aberrant changes in site-specific core fucosylation (CF) of serum proteins contribute to
cancer development and progression, which enables them as potential diagnostic markers …

Opportunities to address gaps in early detection and improve outcomes of liver cancer

B McMahon, C Cohen, RS Brown Jr… - JNCI Cancer …, 2023 - academic.oup.com
Death rates from primary liver cancer (hepatocellular carcinoma [HCC]) have continued to
rise in the United States over the recent decades despite the availability of an increasing …

Diagnostic algorithm for subcentimeter hepatocellular carcinoma using alpha-fetoprotein and imaging features on gadoxetic acid–enhanced MRI

P Huang, F Wu, K Hou, C Zhou, Y Xiao, C Wang… - European …, 2024 - Springer
Objective To investigate the role of serum alpha-fetoprotein (AFP) in diagnosing
subcentimeter hepatocellular carcinoma (HCC) on gadoxetic acid–enhanced MRI (EOB …

Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis

D Daher, KS El Dahan, A Cano, M Gonzales… - Clinical …, 2024 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) surveillance is associated with
improved early detection and reduced mortality, although practice patterns and effectiveness …

Methylated SEPT9 assay-based liquid biopsy as a biomarker in molecular targeted agent-treated hepatocellular carcinoma

I Saeki, Y Suehiro, Y Yamauchi, T Hoshida… - Hepatology …, 2023 - Springer
Background The development of molecular targeted agents (MTAs) has changed the
treatment strategy for hepatocellular carcinoma (HCC). However, currently, there are no …

Precise Capture and Dynamic Release of Circulating Liver Cancer Cells with Dual‐Histidine‐Based Cell Imprinted Hydrogels

W Sun, X You, X Zhao, X Zhang, C Yang… - Advanced …, 2024 - Wiley Online Library
Circulating tumor cells (CTCs) detection presents significant advantages in diagnosing liver
cancer due to its noninvasiveness, real‐time monitoring, and dynamic tracking. However …

Battle of the biopsies: role of tissue and liquid biopsy in hepatocellular carcinoma

BM Lehrich, J Zhang, SP Monga, R Dhanasekaran - Journal of Hepatology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) diagnosis and management have undergone significant
improvements in recent years. With the introduction of immunotherapy-based combination …

Early detection of hepatocellular carcinoma: roadmap for improvement

J Melendez-Torres, AG Singal - Expert review of anticancer …, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) has a poor prognosis, related, in part, to
frequent late-stage diagnosis. Improved implementation of effective HCC surveillance is …