TGF-β signaling and resistance to cancer therapy
M Zhang, YY Zhang, Y Chen, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …
Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy
T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
The relationship between chronic inflammation and neoplastic diseases is not fully
understood. The inflammatory microenvironment of a tumor is an intricate network that …
understood. The inflammatory microenvironment of a tumor is an intricate network that …
The pathogenesis of cardiac fibrosis: a review of recent progress
K Maruyama, K Imanaka-Yoshida - International journal of molecular …, 2022 - mdpi.com
Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas
XY Fu-Shin, PSY Lee, L Yang, N Gao, Y Zhang… - Progress in retinal and …, 2022 - Elsevier
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …
several underlying pathophysiological mechanisms, some of which are still uncertain. The …
Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy
B Mirlekar - SAGE open medicine, 2022 - journals.sagepub.com
Cytokines play a critical role in regulating host immune response toward cancer and
determining the overall fate of tumorigenesis. The tumor microenvironment is dominated …
determining the overall fate of tumorigenesis. The tumor microenvironment is dominated …
Allogeneic natural killer cell therapy
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
Immune responses to retinal gene therapy using adeno-associated viral vectors–Implications for treatment success and safety
K Bucher, E Rodríguez-Bocanegra… - Progress in retinal and …, 2021 - Elsevier
Recombinant adeno-associated virus (AAV) is the leading vector for gene therapy in the
retina. As non-pathogenic, non-integrating, replication deficient vector, the recombinant virus …
retina. As non-pathogenic, non-integrating, replication deficient vector, the recombinant virus …
TGF-β signaling: from tissue fibrosis to tumor microenvironment
JYF Chung, MKK Chan, JSF Li, ASW Chan… - International Journal of …, 2021 - mdpi.com
Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …
Synergistic efficacy of simultaneous anti-TGF-β/VEGF bispecific antibody and PD-1 blockade in cancer therapy
M Niu, M Yi, Y Wu, L Lyu, Q He, R Yang, L Zeng… - Journal of Hematology & …, 2023 - Springer
Background Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and
its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However …
its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However …
Tumor associated macrophages: origin, recruitment, phenotypic diversity, and targeting
The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …
with various components being involved in tumor suppression and tumor growth. A …