The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of
the noncanonical NF-κB pathway, has important roles in regulating immunity and …

Early-life cues shape the immune system during adulthood. However, early-life signaling
pathways and their temporal functions are not well understood. Herein, we demonstrate that …

Inflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by
episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system …

Infectious diseases continue to inflict a high global disease burden. The consensus is that
vaccination is the most effective option against infectious diseases. Oral vaccines have …

Microglia have been implicated in neuroinflammatory diseases, including multiple sclerosis
and its animal model experimental autoimmune encephalomyelitis (EAE). We demonstrate …

Intestinal immunity and homeostasis are maintained through the regulation of cytokine
trafficking, microbiota, necrosis and apoptosis. Intestinal immunity and homeostasis …

Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug
effect. There are multiple hypotheses to explain the development of MRONJ. Reduced bone …