Normal wound healing progresses through inflammatory, proliferative and remodeling
phases in response to tissue injury. Collagen, a key component of the extracellular matrix …

Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The
mechanisms by which ECM regulates its contacting cells have been extensively studied …

The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in
all human tissues. It is comprised of varying proteins, including collagens, elastin, and …

Despite being the hallmark of cancer that is responsible for the highest number of deaths,
very little is known about the biology of metastasis. Metastatic disease typically manifests …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of
solid tumours that plays a crucial role in shaping their progression. Many desmoplastic …

Macrophages can be affected by a variety of factors to change their phenotype and thus
affect their function. Activated macrophages are usually divided into two categories, M1-like …