The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …

Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts
including plants and insects. The dynamic infection process requires rapid and fine-tuning …

Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Invasive fungal infections (IFIs) pose a serious clinical problem, but the antifungal arsenal is
limited and has many disadvantages, such as drug resistance and toxicity. Hence, there is …

Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …

Cryptococcus neoformans is a dimorphic fungus that causes lethal meningoencephalitis
mainly in immunocompromised individuals. Different morphotypes enable this …

The emergence of drug-resistant fungi poses a continuously increasing threat to human
health. Despite advances in preventive care and diagnostics, resistant fungi continue to …

Invasive fungal infections remain a challenge due to lack of effective antifungal agents and
serious drug resistance. Discovery of antifungal agents with novel antifungal mechanism is …

Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of
these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic …