The COVID-19 pandemic constitutes an arduous global health challenge, and the
increasing number of fatalities calls for the speedy pursuit of a remedy. This review …

NK cells are lymphocytes of the innate immune system, which are able to deal promptly with
stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that …

SARS-CoV-2 is the causative agent of the immune response-driven disease COVID-19 for
which new antiviral and anti-inflammatory treatments are urgently needed to reduce …

This chapter aims to describe and review the main important cytokines types (notably
interferons), including their biological activities, functions and structures. As a high number …

Type I interferons (IFNs) are pleiotropic cytokines, initially described for their antiviral activity.
These cytokines exhibit a long record of clinical use in patients with some types of cancer …

Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the
control of HIV replication and initiation of immunologic damage remains debated. In acute …

Summary Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of
many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its …

Nervous necrosis virus (NNV) causes high mortalities in several marine species. We aimed
to evaluate the innate cell-mediated cytotoxic (CMC) activity of head-kidney leucocytes …

The immune network is an effective network of cell types and chemical compounds
established to maintain the body's homeostasis from foreign threats and to prevent the risk of …

Influenza A virus (IAV) is a major respiratory pathogen that causes seasonal and pandemic
flu, being a threat to global health. Various viral and cellular factors have been characterized …