Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

The retina and brain share similar neurochemistry and neurodevelopmental origins, with the
retina, often viewed as a “window to the brain.” With retinal measures of structure and …

Resting-state functional connectivity (RSFC) is a powerful tool for characterizing brain
changes, but it has yet to reliably predict higher-order cognition. This may be attributed to …

Clinical trials for central nervous system disorders often enroll patients with unrecognized
heterogeneous diseases, leading to costly trials that have high failure rates. Here, we …

Human behavior operates within a delicate balance, oscillating between varying degrees of
freedom and sharp points of constraint. Among the most potent constraints that can limit our …

At a group level, nicotine dependence is linked to differences in resting-state functional
connectivity (rs-FC) within and between three large-scale brain networks: the salience …

Traumatic Brain Injury (TBI) is a prevalent disorder mostly characterized by persistent
impairments in cognitive function that poses a substantial burden on caregivers and the …

Neurodegenerative diseases are associated with heterogeneity in genetics, pathology, and
clinical manifestation. Understanding this heterogeneity is particularly relevant for clinical …

Fig. 1 The emergence of subtypes. A We empirically demonstrated three separable domains
of function (green: Approach Behavior, blue: Executive Function, red: Negative Emotionality) …

Associations between connectivity networks and behavioral outcomes such as depression
are typically examined by comparing average networks between known groups. However …