[HTML][HTML] Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

E Ahire, S Thakkar, M Darshanwad, M Misra - Acta pharmaceutica sinica B, 2018 - Elsevier
Advancements in in silico techniques of lead molecule selection have resulted in the failure
of around 70% of new chemical entities (NCEs). Some of these molecules are getting …

Lipid-based emulsion drug delivery systems—A comprehensive review

M Dhaval, P Vaghela, K Patel, K Sojitra, M Patel… - Drug Delivery and …, 2022 - Springer
Lipid-based emulsion system—a subcategory of emulsion technology, has emerged as an
enticing option to improve the solubility of the steadily rising water-insoluble candidates …

pH-induced complex coacervation of fish gelatin and carboxylated chitosan: Phase behavior and structural properties

C Cheng, Z Tu, H Wang - Food Research International, 2023 - Elsevier
The aim of this study was to investigate the phase behavior and structural properties of fish
gelatin complex coacervation with carboxylated chitosan as a function of pH by varying the …

Nanosystem trends in drug delivery using quality-by-design concept

J Li, Y Qiao, Z Wu - Journal of Controlled Release, 2017 - Elsevier
Quality by design (QbD) has become an inevitable trend because of its benefits for product
quality and process understanding. Trials have been conducted using QbD in nanosystems' …

Effect of nanovesicular surface-functionalization via chitosan and/or PEGylation on cytotoxicity of tamoxifen in induced-breast cancer model

MA Megahed, HS El-Sawy, AM Reda, FI Abd-Allah… - Life Sciences, 2022 - Elsevier
Aims The effect of surface-modification of Tamoxifen (Tam)-loaded-niosomes on drug
cytotoxicity and bio-distribution, via functionalization with chitosan and/or PEGylation, was …

α-Amylase-and redox-responsive nanoparticles for tumor-targeted drug delivery

Y Li, H Hu, Q Zhou, Y Ao, C Xiao, J Wan… - … applied materials & …, 2017 - ACS Publications
Paclitaxel (PTX) is an effective antineoplastic agent and shows potent antitumor activity
against a wide spectrum of cancers. Yet, the wide clinical use of PTX is limited by its poor …

Investigation on complex coacervation between fish skin gelatin from cold-water fish and gum arabic: Phase behavior, thermodynamic, and structural properties

Y Li, X Zhang, Y Zhao, J Ding, S Lin - Food research international, 2018 - Elsevier
The study is aimed to investigate phase behavior, thermodynamic, and structural properties
based on complex coacervation between fish skin gelatin (FSG) from cold-water fish and …

Amphiphilic polymeric micelles based on deoxycholic acid and folic acid modified chitosan for the delivery of paclitaxel

L Li, N Liang, D Wang, P Yan, Y Kawashima… - International journal of …, 2018 - mdpi.com
The present investigation aimed to develop a tumor-targeting drug delivery system for
paclitaxel (PTX). The hydrophobic deoxycholic acid (DA) and active targeting ligand folic …

Residual solvents in nanomedicine and lipid-based drug delivery systems: a case study to better understand processes

A Dikpati, F Mohammadi, K Greffard, C Quéant… - Pharmaceutical …, 2020 - Springer
Purpose Complexities surrounding the manufacture and quality control of nanomedicines
become increasingly apparent. This research article offers a case study to investigate how …

Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement

J He, Y Han, G Xu, L Yin, MN Neubi, J Zhou, Y Ding - RSC advances, 2017 - pubs.rsc.org
Celecoxib (CLX) is a selective cyclooxygenase-2 (COX-2) inhibitor; however, the application
of CLX is compromised due to its poor aqueous solubility and low oral bioavailability. This …