G× E interactions as a basis for toxicological uncertainty
To transfer toxicological findings from model systems, eg animals, to humans, standardized
safety factors are applied to account for intra-species and inter-species variabilities. An …
safety factors are applied to account for intra-species and inter-species variabilities. An …
Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells
A Cherianidou, F Kappenberg, F Seidel… - Cell Death …, 2023 - nature.com
Animal studies for embryotoxicity evaluation of potential therapeutics and environmental
factors are complex, costly, and time-consuming. Often, studies are not of human relevance …
factors are complex, costly, and time-consuming. Often, studies are not of human relevance …
Risk assessment of parabens in a transcriptomics-based in vitro test
F Seidel, F Kappenberg, S Fayyaz… - Chemico-Biological …, 2023 - Elsevier
Parabens have been used for decades as preservatives in food, drugs and cosmetics. The
majority however, were banned in 2009 and 2014 leaving only methyl-, ethyl-, propyl-, and …
majority however, were banned in 2009 and 2014 leaving only methyl-, ethyl-, propyl-, and …