Mechanisms of microtubule organization in differentiated animal cells

A Akhmanova, LC Kapitein - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

The tubulin code and its role in controlling microtubule properties and functions

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Chemically fueled self‐assembly in biology and chemistry

K Das, L Gabrielli, LJ Prins - Angewandte Chemie International …, 2021 - Wiley Online Library
Life is a non‐equilibrium state of matter maintained at the expense of energy. Nature uses
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …

Non-equilibrium steady states in catalysis, molecular motors, and supramolecular materials: why networks and language matter

I Aprahamian, SM Goldup - Journal of the American Chemical …, 2023 - ACS Publications
All chemists are familiar with the idea that, at equilibrium steady state, the relative
concentrations of species present in a system are predicted by the corresponding …

Microtubules and microtubule-associated proteins

HV Goodson, EM Jonasson - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

Microtubule dynamics: an interplay of biochemistry and mechanics

GJ Brouhard, LM Rice - Nature reviews Molecular cell biology, 2018 - nature.com
Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

[HTML][HTML] The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Phase separation of EB1 guides microtubule plus-end dynamics

X Song, F Yang, T Yang, Y Wang, M Ding, L Li… - Nature Cell …, 2023 - nature.com
In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …

Therapeutic strategies to overcome taxane resistance in cancer

T Das, U Anand, SK Pandey, CR Ashby Jr… - Drug Resistance …, 2021 - Elsevier
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

H Zhang, X Ji, P Li, C Liu, J Lou, Z Wang… - Science China Life …, 2020 - Springer
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …