Secondary metabolites are divided into three classes: phenolic, terpenoid, and nitrogenous
compounds. Phenolic compounds are also known as polyphenols and include tannins …

Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been
attributed to a combination of genetic, environmental and metabolic factors. Chronic …

Sepsis is a dysregulated systemic inflammatory response caused by infection that leads to
multiple organ injury and high mortality without effective treatment. Corilagin, a natural …

Cardiovascular disease (CVD) is the number one cause of death in the world and seriously
threatens human health. Pyroptosis is a new type of cell death discovered in recent years …

Ischemic stroke (IS) is the second leading cause of death and disability in the world.
Pyroptosis, a form of programmed cell death initiated by caspases, participates in the …

Long intergenic non-coding RNA 00657 (linc00657) is involved in various diseases,
whereas its role in atherosclerosis (AS) development remains inconclusive. This study was …

Background Doxorubicin (DOX) is a potent anticancer chemotherapeutic agent whose
clinical application is substantially constrained by its cardiotoxicity. The pathophysiology of …

Background The NLRP3 inflammasome is a vital player in the emergence of inflammation.
The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation …

The NLRP3 inflammasome, which belongs to the pyrin domain containing 3 family of NOD-
like receptors, has a significant impact on both the innate and adaptive immune responses …

Objective: This paper briefly reviews the structure and function of NLRP3 inflammasomes,
signaling pathway, relationship with synovitis in KOA, and intervention of traditional Chinese …