[HTML][HTML] GSK-3 and Tau: a key duet in Alzheimer's disease
CL Sayas, J Ávila - Cells, 2021 - mdpi.com
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …
Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer's disease neurons
R Rajmohan, PH Reddy - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …
Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …
and mortality in aged population. Several transcription molecules, pathways, and molecular …
The physiology, signaling, and pharmacology of dopamine receptors
JM Beaulieu, RR Gainetdinov - Pharmacological reviews, 2011 - ASPET
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …
[HTML][HTML] Dopamine receptors and neurodegeneration
Dopamine (DA) is one of the major neurotransmitters and participates in a number of
functions such as motor coordination, emotions, memory, reward mechanism …
functions such as motor coordination, emotions, memory, reward mechanism …
Emerging roles of Wnts in the adult nervous system
NC Inestrosa, E Arenas - Nature Reviews Neuroscience, 2010 - nature.com
The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …
[HTML][HTML] Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression
The effects of transcranial direct current stimulation (tDCS) on brain functions and the
underlying molecular mechanisms are yet largely unknown. Here we report that mice …
underlying molecular mechanisms are yet largely unknown. Here we report that mice …
[HTML][HTML] GSK-3 inhibitors: preclinical and clinical focus on CNS
H Eldar-Finkelman, A Martinez - Frontiers in molecular neuroscience, 2011 - frontiersin.org
Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …
become an important strategy for treating neurodegenerative and psychiatric disorders. The …
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways …
This paper reviews new drug targets in the treatment of depression and new drug
candidates to treat depression. Depression is characterized by aberrations in six intertwined …
candidates to treat depression. Depression is characterized by aberrations in six intertwined …
Akt/GSK3 signaling in the action of psychotropic drugs
JM Beaulieu, RR Gainetdinov… - Annual review of …, 2009 - annualreviews.org
Psychotropic drugs acting on monoamine neurotransmission are major pharmacological
treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar …
treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar …