The application of nanotechnology in medicine has the potential to make a great impact on
human health, ranging from prevention to diagnosis and treatment of disease. The kidneys …

Background Angiogenesis is the process of neovascularization from pre-existing
vasculature and is involved in various physiological and pathological processes. Inhibitors …

Renovascular disease remains among the most prevalent and important causes of
secondary hypertension and renal dysfunction. Many lesions reduce perfusion pressure …

Acute kidney injury (AKI) is defined as a pathological condition in which the glomerular
filtration rate decreases rapidly over a short period of time, resulting in changes in the …

Background: MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs that regulate
gene expression and function, but little is known about regulation of miRNAs in the kidneys …

Tubulointerstitial hypoxia and peritubular capillary rarefaction are typical features of chronic
progressive renal disease. In response to low oxygen supply, hypoxia-inducible factors …

The kidney is a highly vascularized organ that normally receives a fifth of the cardiac output.
The unique spatial arrangement of the kidney vasculature with each nephron is crucial for …

Three decades ago a revolutionary idea was born that ascribed to dysfunctional endothelia
some manifestations of diabetes, the Steno hypothesis, so named after the Steno Diabetes …

Renal fibrosis is a common progressive kidney disease, and there is a lack of efficient
treatment for the condition. In this study, we designed a kidney-specific nanocomplex by …

Renovascular hypertension has been recognized for more than 80 years, since seminal
experimental studies showed that progressive occlusion of the renal vessels produces an …