Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

The essential function of the circulatory system is to continuously and efficiently supply the
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …

Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …

Detyrosinated microtubules provide mechanical resistance that can impede the motion of
contracting cardiomyocytes. However, the functional effects of microtubule detyrosination in …

Reversible detyrosination of α-tubulin is crucial to microtubule dynamics and functions, and
defects have been implicated in cancer, brain disorganization, and cardiomyopathies. The …

INTRODUCTION Along with its well-documented role as a track for cargo transport, the
microtubule (MT) cytoskeleton is linked to diverse structural and signaling roles in the …

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …

The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal
tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The …

Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …