Microtubule organization, dynamics and functions in differentiated cells
A Muroyama, T Lechler - Development, 2017 - journals.biologists.com
Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …
about how microtubule organization and dynamics are controlled in cultured cells in vitro …
[HTML][HTML] The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
DGS Wilson, A Tinker, T Iskratsch - Communications Biology, 2022 - nature.com
Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …
Proteomic and functional studies reveal detyrosinated tubulin as treatment target in sarcomere mutation-induced hypertrophic cardiomyopathy
M Schuldt, J Pei, M Harakalova, LM Dorsch… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart
disease. While≈ 50% of patients with HCM carry a sarcomere gene mutation (sarcomere …
disease. While≈ 50% of patients with HCM carry a sarcomere gene mutation (sarcomere …
[HTML][HTML] Tubulin posttranslational modifications and emerging links to human disease
Tubulin posttranslational modifications are currently emerging as important regulators of the
microtubule cytoskeleton and thus have a strong potential to be implicated in a number of …
microtubule cytoskeleton and thus have a strong potential to be implicated in a number of …
Microtubules as a potential platform for energy transfer in biological systems: a target for implementing individualized, dynamic variability patterns to improve organ …
Y Ilan - Molecular and Cellular Biochemistry, 2023 - Springer
Variability characterizes the complexity of biological systems and is essential for their
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …
Cardiac microtubules in health and heart disease
MA Caporizzo, CY Chen… - Experimental Biology and …, 2019 - journals.sagepub.com
Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …
working force behind each heartbeat. These highly structured cells are packed with dense …
[HTML][HTML] Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle
While the importance of RNA localization in highly differentiated cells is well appreciated,
basic principles of RNA localization in skeletal muscle remain poorly characterized. Here …
basic principles of RNA localization in skeletal muscle remain poorly characterized. Here …
[HTML][HTML] Back to the tubule: microtubule dynamics in Parkinson's disease
Cytoskeletal homeostasis is essential for the development, survival and maintenance of an
efficient nervous system. Microtubules are highly dynamic polymers important for neuronal …
efficient nervous system. Microtubules are highly dynamic polymers important for neuronal …
A family of carboxypeptidases catalyzing α-and β-tubulin tail processing and deglutamylation
S Nicot, G Gillard, H Impheng, E Joachimiak… - Science …, 2023 - science.org
Tubulin posttranslational modifications represent an important mechanism involved in the
regulation of microtubule functions. The most widespread among them are detyrosination …
regulation of microtubule functions. The most widespread among them are detyrosination …
Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress
How breast cancer and its treatments affect skeletal muscle is not well defined. To address
this question, we assessed skeletal muscle structure and protein expression in 13 women …
this question, we assessed skeletal muscle structure and protein expression in 13 women …