Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart
disease. While≈ 50% of patients with HCM carry a sarcomere gene mutation (sarcomere …

Tubulin posttranslational modifications are currently emerging as important regulators of the
microtubule cytoskeleton and thus have a strong potential to be implicated in a number of …

Variability characterizes the complexity of biological systems and is essential for their
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

While the importance of RNA localization in highly differentiated cells is well appreciated,
basic principles of RNA localization in skeletal muscle remain poorly characterized. Here …

Cytoskeletal homeostasis is essential for the development, survival and maintenance of an
efficient nervous system. Microtubules are highly dynamic polymers important for neuronal …

Tubulin posttranslational modifications represent an important mechanism involved in the
regulation of microtubule functions. The most widespread among them are detyrosination …

How breast cancer and its treatments affect skeletal muscle is not well defined. To address
this question, we assessed skeletal muscle structure and protein expression in 13 women …