Aging is a complex feature and involves loss of multiple functions and nonreversible
phenotypes. However, several studies suggest it is possible to protect against aging and …

Background Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD)
are characterized by muscle wasting leading to loss of ambulation in the first or third decade …

Background: Diastolic dysfunction is a prevalent and therapeutically intractable feature of
heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but …

Among the variety of post-translational modifications to which microtubules are subjected,
the detyrosination/re-tyrosination cycle is specific to tubulin. It is conserved by evolution and …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Properly patterned deposition of cell wall polymers is prerequisite for the morphogenesis of
plant cells. A cortical microtubule array guides the two-dimensional pattern of cell wall …

Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

Microtubules are subjected to a variety of post-translational modifications (PTMs). The
combination of different α-and β-tubulin isoforms and PTMs are referred to as the tubulin …

The adaptation of the skeleton to its mechanical environment is orchestrated by
mechanosensitive osteocytes, largely by regulating the abundance of sclerostin, a secreted …

Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …