The composition and the stiffness of cardiac microenvironment change during development
and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes …

Reversible detyrosination of tubulin, the building block of microtubules, is crucial for
neuronal physiology. Enzymes responsible for detyrosination were recently identified as …

Microtubules, a highly dynamic cytoskeleton, participate in many cellular activities including
mechanical support, organelles interactions, and intracellular trafficking. Microtubule …

The downregulation of sclerostin in osteocytes mediates bone formation in response to
mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has …

Vasohibins are tubulin tyrosine carboxypeptidases that are important in neuron physiology.
We examined the crystal structures of human vasohibin 1 and 2 in complex with small …

Incorrect kinetochore–microtubule attachments during mitosis can lead to chromosomal
instability, a hallmark of human cancers. Mitotic error correction relies on the kinesin-13 …

Mechanical forces impact cardiac cells and tissues over their entire lifespan, from
development to growth and eventually to pathophysiology. However, the mechanobiological …

The mechanical environment of the myocardium has a potent effect on cardiomyocyte form
and function, yet an understanding of the cardiomyocyte responses to extracellular stiffening …

Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

Microtubules (MTs) are the most rigid elements of the cytoskeleton with in vitro persistence
lengths (L p) in the range of 1–6 mm. In cellular environments, however, MTs often appear …