Structural centrosome aberrations promote non‐cell‐autonomous invasiveness

O Ganier, D Schnerch, P Oertle, RYH Lim… - The EMBO …, 2018 - embopress.org
Centrosomes are the main microtubule‐organizing centers of animal cells. Although
centrosome aberrations are common in tumors, their consequences remain subject to …

The mechanical microenvironment in breast cancer

SJP Pratt, RM Lee, SS Martin - Cancers, 2020 - mdpi.com
Mechanotransduction is the interpretation of physical cues by cells through
mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical …

Cardiac myoediting attenuates cardiac abnormalities in human and mouse models of Duchenne muscular dystrophy

A Atmanli, AC Chai, M Cui, Z Wang… - Circulation …, 2021 - Am Heart Assoc
Rationale: Absence of dystrophin in Duchenne muscular dystrophy (DMD) results in the
degeneration of skeletal and cardiac muscles. Owing to advances in respiratory …

The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism

C Henriquez-Olguin, S Boronat… - Antioxidants & Redox …, 2019 - liebertpub.com
Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic
health. Reactive oxygen species (ROS) have emerged as intracellular messengers …

Targeting microtubules for the treatment of heart disease

EF Warner, Y Li, X Li - Circulation Research, 2022 - Am Heart Assoc
Heart disease remains the leading cause of morbidity and mortality worldwide. With the
advancement of modern technology, the role (s) of microtubules in the pathogenesis of heart …

[HTML][HTML] Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies

IC Valera, AL Wacker, HS Hwang, C Holmes… - Advances in medical …, 2021 - Elsevier
The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically
remodels during cardiac disease. This review examines DGC remodeling as a common …

NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

JA Loehr, S Wang, TR Cully, R Pal, IV Larina, KV Larin… - Elife, 2018 - elifesciences.org
Skeletal muscle from mdx mice is characterized by increased Nox2 ROS, altered
microtubule network, increased muscle stiffness, and decreased muscle/respiratory function …

Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote …

JL McCourt, KM Stearns-Reider, H Mamsa, P Kannan… - Skeletal muscle, 2023 - Springer
Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of
the muscle cell membrane, providing a mechanical link between the extracellular matrix …

[HTML][HTML] A systems approach using the functional resonance analysis method to support fluoride varnish application for children attending general dental practice

A Ross, A Sherriff, J Kidd, W Gnich, J Anderson… - Applied ergonomics, 2018 - Elsevier
Abstract Background All children attending General Dental Practice in Scotland are
recommended to receive twice-yearly applications of sodium fluoride varnish to prevent …

[HTML][HTML] Rabbit models of cardiac mechano-electric and mechano-mechanical coupling

TA Quinn, P Kohl - Progress in biophysics and molecular biology, 2016 - Elsevier
Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics
in the heart. Whereas mechanical activity is usually seen as 'the endpoint'of cardiac auto …