[HTML][HTML] Reversing memory/cognitive impairment with medicinal plants targeting inflammation and its crosstalk with other pathologies

SEB Tyler, LDK Tyler - Brain Disorders, 2023 - Elsevier
Inflammation has a key role in driving memory/cognitive impairment in conditions ranging
from Alzheimer's disease, vascular dementia, Parkinson's disease, traumatic brain injury …

Fluoxetine attenuates chlorpyrifos-induced neuronal injury through the PPARγ, SIRT1, NF-κB, and JAK1/STAT3 signals

HS Althagafy, EHM Hassanein - International Immunopharmacology, 2024 - Elsevier
Chlorpyrifos (CPF) is a widely used organophosphate insecticide in agriculture and homes.
Exposure to organophosphates is associated with neurotoxicity. Fluoxetine (FLX) is a …

Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway

Y Yang, Y Lai, X Tong, Z Li, Y Cheng… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Neuroinflammation is involved in the pathogenesis of
depression disorder by activating microglia cells, increasing proinflammatory cytokines …

Discovery and verification of antidepressant active ingredients of raw and vinegar-processed Bupleurum marginatum var. Stenophyllum based on plant metabolomics …

Z Qu, Y Bing, S Wu, H Wang, J Wang, X Ji… - … of Pharmaceutical and …, 2024 - Elsevier
The dried root of Bupleurum marginatum var. stenophyllum (H. Wolff) RH Shan & Y. Li (BM),
which has been used as a Bupleuri radix in Guizhou Province and is listed in the 2003 …

Merazin hydrate produces rapid antidepressant effects by activating CaMKII to promote neuronal activities and proliferation in hippocampus

Z Gao, C Lu, Y Zhu, Y Liu, Y Lin, W Gao, L Tian, L Wu - Brain Research, 2024 - Elsevier
In our previous studies, we demonstrated that merazin hydrate (MH) had rapid
antidepressant effects, but the deep mechanism needed to be further investigated. In this …

[HTML][HTML] Effects of Subchronic Propofol Administration on the Proliferation and Differentiation of Neural Stem Cells in Rat Hippocampus

C Chang, W Bai, J Li, S Huo, T Wang, J Shao - Current Therapeutic …, 2023 - Elsevier
Background Although controversial, experimental data suggest the use of propofol may be
associated with neurotoxicity. The mechanisms responsible for propofol neurotoxicity in …

[HTML][HTML] The Platelet Serotonergic System and the Search for New Biomarkers and Therapeutic Options for Diverse Diseases

The latest advances in basic and clinical research on the main components of the platelet
serotonergic system are presently reviewed. These components consist of serotonin (5-HT) …

[HTML][HTML] Study the effects of empagliflozin on model of chronic depression and interleukin-6 in the brain of male rats

HK Mijwel, SM Selman… - Medical Journal of …, 2023 - journals.lww.com
Background: Empagliflozin (EMP) is an oral anti-diabetic drug with pleiotropic effects such
as anti-inflammatory properties. Objectives: To evaluate the antidepressant effect of EMP …

Plasma Exosomal Derived CCDC18AS1/miR-6835-5p/CCND2 Axis Sever as Biomarkers for Diagnosis and Predicting Efficacy of Adolescent with Major Depressive …

Z Liu, Y Xu, X Du, R Zhang, Y Huang, Y Gao, Y Wen… - 2023 - researchsquare.com
Major depressive disorder (MDD) in adolescence seriously endangers their mental and
physical health and is associated with poor social and scholastic function. However, the …

Mechanism of fluoxetine downregulation of circMap2k1 to alleviate neurological function after ischemic stroke

H Zhang, J Deng, Y He, Z Cai, Y He - 2023 - researchsquare.com
Background Ischemic stroke (IS) is known for its high incidence, disability and mortality, and
there is an urgent need to investigate the pathophysiological mechanisms and develop …