The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Interplay among immune activation and cancer pathogenesis provides the framework for a
novel subspecialty known as immunooncology. In the rapidly evolving field of …

Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer
immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell …

Lycopene is a well-known compound found commonly in tomatoes which brings wide range
of health benefits against cardiovascular diseases and cancers. From an anti-cancer …

Surgical resection is an important avenue for cancer treatment, which, in most cases, can
effectively alleviate the patient symptoms. However, accumulating evidence has …

Complement C1q is the activator of the classical pathway. However, it is now recognized
that C1q can exert functions unrelated to complement activation. Here we show that C1q, but …

Disruption of the programmed cell death protein 1 (PD-1) pathway with immune checkpoint
inhibitors represents a major breakthrough in the treatment of non–small cell lung cancer …

Comprehensive proteome quantification is crucial for a better understanding of underlying
mechanisms of diseases. Liquid chromatography mass spectrometry (LC-MS) has become …