The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Orally targeted strategy of anti-inflammatory agents has attracted tremendous attention for
reducing highly health-care costs and enhancing the intervention efficiency of ulcerative …

Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs)
family, is located downstream of the pattern recognition receptors (PRRs)-mediated …

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates
with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 …

Background Shift work is associated with increased risk of acute myocardial infarction (AMI)
and worsened prognosis. However, the mechanisms linking shift work and worsened …

Hyperandrogenism is the main cause of infertility as a result of polycystic ovary syndrome
(PCOS). Long-term and continuous exposure to hyperandrogen can cause follicular …

The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

Background Circadian disturbance is a common nonmotor complaint in Parkinson's disease
(PD). The molecular basis underlying circadian rhythm in PD is poorly understood …

Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …