The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Intratumoral heterogeneity is a critical frontier in understanding how the tumor
microenvironment (TME) propels malignant progression. Here, we deconvolute the human …

Primary tumors are drivers of pre-metastatic niche formation, but the coordination by the
secondary organ toward metastatic dissemination is underappreciated. Here, by single-cell …

Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor
immune response through the release of pro-inflammatory cytokines and immunogenic …

Breast cancer is one of the most common malignancies among women throughout the world
and is the major cause of most cancer-related deaths. Several explanations account for the …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Colorectal cancer (CRC) patients, especially those with deficient mismatch repair
(dMMR)/microsatellite instability-high (MSI-H) tumors, whose sensitivity to immune …