Fibroblasts in the tumor microenvironment, known as cancer-associated fibroblasts (CAFs),
promote the migration, invasion, and metastasis of cancer cells when they are activated …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

Emerging evidence suggests that not only the frequency and composition of tumor-
infiltrating leukocytes but also their spatial organization might be a major determinant of …

Abstract Heat shock factor 1 (HSF1) systematically guards proteome stability and
proteostasis by regulating the expression of heat shock protein (HSP), thus rendering cancer …

Given the complexity, heterogeneity and metastasis of patient tumors, the combined therapy
is usually applied in clinical applications. Internal radioisotope therapy has been an …

Distant metastasis remains a leading cause of mortality among patients with colorectal
cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific …

Dysregulated expression of S100A7 is found in several cancers and plays an important role
in tumor progression; however, its carcinogenic role in esophageal squamous carcinoma …

Lung cancer is the most commonly diagnosed cancer and accounts for most cancer-related
mortalities worldwide. The high expression of programmed death ligand 1 (PD-L1) is an …

Lung adenocarcinoma, the most prevalent lung cancer subtype, is characterized by its high
propensity to metastasize. Despite the importance of metastasis in lung cancer mortality, its …

Although most cell membrane proteins are modified by glycosylation, our understanding of
the role and actions of protein glycosylation is still very limited. β1, 3galactosyltransferase …