Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases

Z Zhao, A Ukidve, V Krishnan, A Fehnel… - Nature Biomedical …, 2021 - nature.com
Eliciting immune responses against primary tumours is hampered by their
immunosuppressive microenvironment and by the greater inaccessibility of deeper …

Photocatalytic Pt (IV)‐Coordinated Carbon Dots for Precision Tumor Therapy

D Guo, JH Lei, D Rong, T Zhang, B Zhang… - Advanced …, 2022 - Wiley Online Library
Rapid, efficient, and precise cancer therapy is highly desired. Here, this work reports
solvothermally synthesized photoactivatable Pt (IV)‐coordinated carbon dots (Pt‐CDs) and …

[HTML][HTML] Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy

Y Guo, Q Bao, P Hu, J Shi - Nature Communications, 2023 - nature.com
Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy.
Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral …

[HTML][HTML] Insights into lung cancer immune-based biology, prevention, and treatment

S Saab, H Zalzale, Z Rahal, Y Khalifeh… - Frontiers in …, 2020 - frontiersin.org
Lung cancer is the number one cause of cancer-related deaths. The malignancy is
characterized by dismal prognosis and poor clinical outcome mostly due to advanced-stage …

[HTML][HTML] Macrophage-related SPP1 as a potential biomarker for early lymph node metastasis in lung adenocarcinoma

B Dong, C Wu, L Huang, Y Qi - Frontiers in cell and developmental …, 2021 - frontiersin.org
Lymph node metastasis is a major factor that affects prognosis in patients with lung
adenocarcinoma (LUAD). In some cases, lymph node metastasis has already occurred …

[HTML][HTML] Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance

A Ajith, K Mamouni, DD Horuzsko… - The Journal of …, 2023 - Am Soc Clin Investig
The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in
development of chronic inflammatory disorders and the inflamed tumor microenvironment …

[HTML][HTML] Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer

KSS Enfield, E Colliver, C Lee, A Magness, DA Moore… - Cancer discovery, 2024 - AACR
Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to
improving patient outcomes. We identified four histology-independent archetype TMEs in …

[HTML][HTML] Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling

L Yu, H Zhu, Z Wang, J Huang, Y Zhu, G Fan, Y Wang… - Molecular Cancer, 2022 - Springer
Background Disappointing clinical efficacy of standard treatment has been proven in
refractory metastatic osteosarcoma, and the emerging anti-angiogenic regimens are still in …

Versatile Nano‐PROTAC‐Induced Epigenetic Reader Degradation for Efficient Lung Cancer Therapy

HT Zhang, R Peng, S Chen, A Shen, L Zhao… - Advanced …, 2022 - Wiley Online Library
Recent evidence has indicated that overexpression of the epigenetic reader bromodomain‐
containing protein 4 (BRD4) contributes to a poor prognosis of lung cancers, and the …

Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages

W Yu, C Hu, H Gao - Advanced Drug Delivery Reviews, 2021 - Elsevier
Breast cancer is the most common tumor in women, and the metastasis further increases the
malignancy with extremely high mortality. However, there is almost no effective method in …