[HTML][HTML] Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures–2019 update: cosponsored …

JI Mechanick, C Apovian, S Brethauer… - Surgery for Obesity and …, 2020 - Elsevier
Objective The development of these updated clinical practice guidelines (CPG) was
commissioned by the American Association of Clinical Endocrinologists, The Obesity …

Depression and obesity: evidence of shared biological mechanisms

Y Milaneschi, WK Simmons, EFC van Rossum… - Molecular …, 2019 - nature.com
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

[HTML][HTML] Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases

J Gutiérrez-Cuevas, A Santos… - International Journal of …, 2021 - mdpi.com
Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …

Mechanisms, pathophysiology, and management of obesity

SB Heymsfield, TA Wadden - New England Journal of Medicine, 2017 - Mass Medical Soc
Obesity is prevalent in the US population and contributes significantly to morbidity and
mortality. Treatments include behavioral therapy, pharmacotherapy, and bariatric surgery …

Obesity, risk of diabetes and role of physical activity, exercise training and cardiorespiratory fitness

S Carbone, MG Del Buono, C Ozemek… - Progress in cardiovascular …, 2019 - Elsevier
The epidemic of obesity contributes to the burden of type 2 diabetes mellitus (T2DM) in the
United States and worldwide. Importantly, obesity is not only preventable but can be treated …

Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications

MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

Genetics and epigenetics in obesity

K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

[HTML][HTML] Obesity subtypes, related biomarkers & heterogeneity

LPC Mayoral, GM Andrade, EPC Mayoral… - Indian Journal of …, 2020 - journals.lww.com
Obesity is a serious medical condition worldwide, which needs new approaches and
recognized international consensus in treating diseases leading to morbidity. The aim of this …