Objective To investigate the prevalence of surfactant dysfunction (SD) and the genotype
distribution in Chinese childhood interstitial lung disease (chILD). Methods From December …

Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease in which the
abnormalities in alveolar surfactant accumulation are caused by impairments of GM-CSF …

Alveolar lining fluid requires surfactant to prevent alveolar collapse at end expiration. This
activity is generated by interactions of phospholipids with the hydrophobic surfactant …

La fibrose pulmonaire idiopathique (FPI) est la forme la plus fréquente de pneumopathie
interstitielle diffuse (PID) idiopathique chronique chez l'adulte, au sein du vaste groupe des …

Interstitial lung disease can be an indication for lung transplant at any age, but it is a
particularly common indication for lung transplant in infants. Nevertheless, not all interstitial …

Context Identification of a frameshift heterozygous mutation in the transcription factor NKX2-
1 in a patient with brain-lung-thyroid syndrome (BLTS) and life-threatening lung …

The American Thoracic Society (ATS) recently published a clinical practice guideline
regarding the classification, evaluation, and management of childhood interstitial lung …

NKX2. 1 encodes the thyroid transcription factor 1 (TTF1), which is implicated in lung
development and control of the expression of surfactant proteins [1]. This transcription factor …

Neonatal lung and heart diseases, albeit rare, can result in poor quality of life, often require
long-term management and/or organ transplantation. For example, Congenital Heart …

Background: Antenatal corticosteroids and surfactant replacement therapy have dramatically
reduced mortality caused by lung disease in premature babies. Knowledge about …