Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …

Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and
pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix …

Abstract Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), a component of
Gram-negative bacteria to induce production of pro-inflammatory mediators aiming at …

Macrophages exhibit phenotypic diversity permitting wide-ranging roles in maintaining
physiologic homeostasis. Hyaluronic acid, a major glycosaminoglycan of the extracellular …

In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

Scavenger receptors constitute a large family of proteins that are structurally diverse and
participate in a wide range of biological functions. These receptors are expressed …

Background Multicellular organisms have evolved systems/mechanisms to detect various
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …

Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid
and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the …