[HTML][HTML] WormBase ParaSite− a comprehensive resource for helminth genomics
The number of publicly available parasitic worm genome sequences has increased
dramatically in the past three years, and research interest in helminth functional genomics is …
dramatically in the past three years, and research interest in helminth functional genomics is …
The Perseus computational platform for comprehensive analysis of (prote) omics data
A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis …
quantitative protein abundance data generated using mass-spectrometry-based analysis …
[HTML][HTML] IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression
A Sadik, LFS Patterson, S Öztürk, SR Mohapatra… - Cell, 2020 - cell.com
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …
have important homeostatic and disease-promoting functions. However, little is known about …
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
A Buniello, JAL MacArthur, M Cerezo… - Nucleic acids …, 2019 - academic.oup.com
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide
association studies enabling investigations to identify causal variants, understand disease …
association studies enabling investigations to identify causal variants, understand disease …
MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data
Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
MAFG-driven astrocytes promote CNS inflammation
Multiple sclerosis is a chronic inflammatory disease of the CNS. Astrocytes contribute to the
pathogenesis of multiple sclerosis, but little is known about the heterogeneity of astrocytes …
pathogenesis of multiple sclerosis, but little is known about the heterogeneity of astrocytes …
Multi-omics profiling of mouse gastrulation at single-cell resolution
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional …
establishment of the vertebrate body plan and is associated with major transcriptional …
A subcellular map of the human proteome
PJ Thul, L Åkesson, M Wiking, D Mahdessian… - Science, 2017 - science.org
INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …
molecular components of its smallest functional unit, the cell. Cells are internally organized …
The human protein atlas: a spatial map of the human proteome
PJ Thul, C Lindskog - Protein Science, 2018 - Wiley Online Library
The correct spatial distribution of proteins is vital for their function and often mis‐localization
or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas …
or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas …