The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …

Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

The broad-based legalization of cannabis use has created a strong need to understand its
impact on human health and behavior. The risks that may be associated with cannabis use …

“K2” and “Spice” drugs (collectively hereafter referred to as Spice) represent a relatively new
class of designer drugs that have recently emerged as popular alternatives to marijuana …

Aims Recently, several synthetic cannabinoids were identified in herbal mixtures consumed
as recreational drugs alternative to cannabis products. The aim was to characterize the …

Synthetic cannabinoids are functionally similar to delta9-tetrahydrocannabinol (THC), the
psychoactive principle of cannabis, and bind to the same cannabinoid receptors in the brain …

Although several chemical structural classes of synthetic cannabinoids (SCs) were recently
classified as Schedule I substances, rates of use and cases of serious toxic effects remain …