One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …

Polyethylenimine (PEI) has recently been widely studied for the design of nucleic acid
delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

MicroRNAs (miRs) play an important role in regulating gene expression. Limited by their
instabilities, miR therapeutics require delivery vehicles. Tetrahedral framework nucleic acids …

Applications for advanced functional soft materials that possess precisely engineered
properties and functional groups have been expanding significantly with the development of …

Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro
and in vivo for DNA and siRNA delivery systems because of their cationic charge …

Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids
over the past two decades. Many previous studies have demonstrated that synthetic delivery …

Numerous non-ionic thermally responsive homopolymers phase separate from their
aqueous solutions upon heating. Far fewer neutral homopolymers are known to phase …

Multiple extra-and intracellular obstacles, including low stability in blood, poor cellular
uptake, and inefficient endosomal escape and disassembly in the cytoplasm, have to be …

Cationic polymers are the subject of intense research as non-viral gene delivery systems,
due to their flexible properties, facile synthesis, robustness, and proven gene delivery …

Microfluidics is an emerging technology that can be employed as a powerful tool for
designing lipid nano-microsized structures for biological applications. Those lipid structures …