The presynaptic protein complexin (CPX) is a critical regulator of synaptic vesicle fusion, but
the mechanisms underlying its regulatory effects are not well understood. Its highly …

Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE
proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central …

Modulation of neurotransmitter exocytosis by activated G i/o coupled G-protein coupled
receptors (GPCRs) is a universal regulatory mechanism used both to avoid overstimulation …

Complexins are small α-helical proteins that modulate neurotransmitter release by binding
to SNARE complexes during synaptic vesicle exocytosis. They have been found to function …

Synaptic transmission occurs when an action potential triggers neurotransmitter release via
the fusion of synaptic vesicles with the presynaptic membrane, driven by the formation of …

Complexin (Cplx) proteins modulate the core SNARE complex to regulate exocytosis. To
understand the contributions of Cplx to signaling in a well-characterized neural circuit, we …

SNARE complexes form between the synaptic vesicle protein synaptobrevin and the plasma
membrane proteins syntaxin and SNAP25 to drive membrane fusion. A cytosolic protein …

Information processing by the nervous system depends on neurotransmitter release from
synaptic vesicles (SVs) at the presynaptic active zone. Molecular components of the …

Complexin is a critical presynaptic protein that regulates both spontaneous and calcium-
triggered neurotransmitter release in all synapses. Although the SNARE-binding central …

Key points• Knockout (KO) of complexin in mouse neuromuscular junctions (NMJs) and
adrenal chromaffin cells causes a reduction and a loss in synchronicity in calcium‐mediated …