Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Tobacco smoking accounts for at least 30% of all cancer deaths and nearly 90% of lung
cancer deaths. Smoking cessation significantly reduces the risk of developing tobacco …

Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular
recreational tool among adolescents and adults. Although the use of ENDS is often …

To identify risk variants for lung cancer, we conducted a multistage genome-wide
association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 …

Lung cancer is the most common cause of cancer death worldwide, with over one million
cases annually. To identify genetic factors that modify disease risk, we conducted a genome …

Cigarette smoking is strongly correlated with the onset of nonsmall cell lung cancer
(NSCLC). Nicotine, an active component of cigarettes, has been found to induce …

Recent studies have shown that nicotine, a component of cigarette smoke, can stimulate the
proliferation of non-neuronal cells. While nicotine is not carcinogenic by itself, it has been …

Nicotinic acetylcholine receptors (nAChRs) constitute a heterogeneous family of ion
channels that mediate fast synaptic transmission in neurons. They have also been found on …

Nicotine-induced cell survival is associated with chemoresistance of human lung cancer
cells, but our understanding of the intracellular mechanism (s) is fragmentary. Bax is a major …

Introduction: Cigarette smoke associated polycyclic aromatic hydrocarbons can induce key
drug-metabolizing enzymes of cytochrome P450 and isoforms of the glucuronyl transferases …