Potential roles of m6A and FTO in synaptic connectivity and major depressive disorder

H Mitsuhashi, C Nagy - International journal of molecular sciences, 2023 - mdpi.com
RNA modifications known as epitranscriptomics have emerged as a novel layer of
transcriptomic regulation. Like the well-studied epigenetic modifications characterized in …

Phase separation of BuGZ regulates gut regeneration and aging through interaction with m6A regulators

Q Zhang, K Deng, M Liu, S Yang, W Xu, T Feng… - Nature …, 2023 - nature.com
Exploring the role of phase separation in intracellular compartment formation is an active
area of research. However, the associations of phase separation with intestinal stem cell …

The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice

R Chang, S Zhu, J Peng, Z Lang, X Zhou, H Liao… - Translational …, 2023 - nature.com
Memory reconsolidation refers to the process by which the consolidated memory was
restored after reactivation (RA). Memory trace becomes labile after reactivation and …

Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target

S Barone, C Cerchia, V Summa… - Journal of Medicinal …, 2024 - ACS Publications
Key epitranscriptomic players have been increasingly characterized for their structural
features and their involvement in several diseases. Accordingly, the design and synthesis of …

The m6A-methylome in major depression: A bioinformatic analysis of publicly available datasets

K Joshi, DO Wang, A Gururajan - Psychiatry Research Communications, 2022 - Elsevier
One of the most common RNA modifications found in the mammalian brain is N6-
methyladenosine (m6A) and this modification has been implicated in fine-tuning neuronal …

Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA

R Zhang, Y Zhang, F Guo, G Huang, Y Zhao… - Cell Death …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered
to have a wide range of effects on learning and memory. Here, we found that the …

[HTML][HTML] Epitranscriptomic analysis of N6-methyladenosine in infant rhesus macaques after multiple sevoflurane anesthesia

X Chen, L Shi, L Zhang, Y Cheng, Z Xue, J Yan… - Neuroscience, 2022 - Elsevier
Clinical investigations to date have proposed the possibility that exposure to anesthetics is
associated with neurodevelopmental deficits. Sevoflurane is the most commonly used …

dTrmt10A impacts Hsp70 chaperone m6A levels and the stress response in the Drosophila brain

AE Perlegos, X Quan, KM Donnelly, H Shen… - Scientific Reports, 2023 - nature.com
Chronic cellular stress has a profound impact on the brain, leading to degeneration and
accelerated aging. Recent work has revealed the vital role of RNA modifications, and the …

No significant change of N6‐methyladenosine modification landscape in mouse brain after morphine exposure

X Wu, C Wu, T Zhou - Brain and Behavior, 2024 - Wiley Online Library
Abstract Objectives N6‐methyladenosine (m6A) plays a crucial role in regulating
neuroplasticity and different brain functions at the posttranscriptional level. However, it …

Dynamics of Fricke–Painlevé VI Surfaces

M Planat, D Chester, K Irwin - Dynamics, 2024 - mdpi.com
The symmetries of a Riemann surface Σ∖{ai} with n punctures ai are encoded in its
fundamental group π 1 (Σ). Further structure may be described through representations …