Potential roles of m6A and FTO in synaptic connectivity and major depressive disorder
H Mitsuhashi, C Nagy - International journal of molecular sciences, 2023 - mdpi.com
RNA modifications known as epitranscriptomics have emerged as a novel layer of
transcriptomic regulation. Like the well-studied epigenetic modifications characterized in …
transcriptomic regulation. Like the well-studied epigenetic modifications characterized in …
Phase separation of BuGZ regulates gut regeneration and aging through interaction with m6A regulators
Q Zhang, K Deng, M Liu, S Yang, W Xu, T Feng… - Nature …, 2023 - nature.com
Exploring the role of phase separation in intracellular compartment formation is an active
area of research. However, the associations of phase separation with intestinal stem cell …
area of research. However, the associations of phase separation with intestinal stem cell …
The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice
R Chang, S Zhu, J Peng, Z Lang, X Zhou, H Liao… - Translational …, 2023 - nature.com
Memory reconsolidation refers to the process by which the consolidated memory was
restored after reactivation (RA). Memory trace becomes labile after reactivation and …
restored after reactivation (RA). Memory trace becomes labile after reactivation and …
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target
Key epitranscriptomic players have been increasingly characterized for their structural
features and their involvement in several diseases. Accordingly, the design and synthesis of …
features and their involvement in several diseases. Accordingly, the design and synthesis of …
The m6A-methylome in major depression: A bioinformatic analysis of publicly available datasets
One of the most common RNA modifications found in the mammalian brain is N6-
methyladenosine (m6A) and this modification has been implicated in fine-tuning neuronal …
methyladenosine (m6A) and this modification has been implicated in fine-tuning neuronal …
Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
R Zhang, Y Zhang, F Guo, G Huang, Y Zhao… - Cell Death …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered
to have a wide range of effects on learning and memory. Here, we found that the …
to have a wide range of effects on learning and memory. Here, we found that the …
[HTML][HTML] Epitranscriptomic analysis of N6-methyladenosine in infant rhesus macaques after multiple sevoflurane anesthesia
X Chen, L Shi, L Zhang, Y Cheng, Z Xue, J Yan… - Neuroscience, 2022 - Elsevier
Clinical investigations to date have proposed the possibility that exposure to anesthetics is
associated with neurodevelopmental deficits. Sevoflurane is the most commonly used …
associated with neurodevelopmental deficits. Sevoflurane is the most commonly used …
dTrmt10A impacts Hsp70 chaperone m6A levels and the stress response in the Drosophila brain
Chronic cellular stress has a profound impact on the brain, leading to degeneration and
accelerated aging. Recent work has revealed the vital role of RNA modifications, and the …
accelerated aging. Recent work has revealed the vital role of RNA modifications, and the …
No significant change of N6‐methyladenosine modification landscape in mouse brain after morphine exposure
X Wu, C Wu, T Zhou - Brain and Behavior, 2024 - Wiley Online Library
Abstract Objectives N6‐methyladenosine (m6A) plays a crucial role in regulating
neuroplasticity and different brain functions at the posttranscriptional level. However, it …
neuroplasticity and different brain functions at the posttranscriptional level. However, it …