In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and
transcribed but never get translated into proteins. Though not translated into proteins …

With rapid development of sequencing technologies such as deep sequencing and whole
genome high-density tiling array, we now know that most of the “junk” genomic sequences …

There is a growing interest for noncoding RNA (ncRNA)-mediated epigenetic regulation of
transcription in diverse biological functions. Recent evidence suggests that a subset of long …

The H19/IGFf2 locus belongs to a large imprinted domain located on human chromosome
11p15. 5 (homologue to mouse distal chromosome 7). The H19 gene is expressed from the …

Genomic analyses have demonstrated that although less than 2% of the mammalian
genome encodes proteins, at least two thirds is transcribed. Many nontranslated RNAs have …

The Kcnq1ot1 antisense noncoding RNA has been implicated in long-range bidirectional
silencing, but the underlying mechanisms remain enigmatic. Here we characterize a domain …

Long noncoding RNAs (lncRNAs) have been implicated in many biological processes
through epigenetic mechanisms. We previously reported that KCNQ1OT1, an imprinted …

Long non-coding RNAs (lncRNAs) have important regulatory functions across eukarya. It is
now clear that many of these functions are related to gene expression regulation through …

The regions of the genome that interact frequently with the nucleolus have been termed
nucleolar-associated domains (NADs). Deep sequencing and DNA-fluorescence in situ …