Acid-base homeostasis and pH regulation are critical for both normal physiology and cell
metabolism and function. The importance of this regulation is evidenced by a variety of …

Acute kidney injury (AKI) is an important health problem, affecting 13.3 million
individuals/year. It is associated with increased mortality, mainly in low-and middle-income …

Acute kidney injury (AKI) is a progressive renal complication which significantly affects the
patient's life with huge economic burden. Untreated acute kidney injury eventually …

Urinary tract infections (UTIs) are among the most common bacterial infections seen in
clinical practice. The ascent of UTI-causing pathogens to the kidneys results in …

Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely accepted
pathophysiologic feature of sepsis-induced acute kidney injury (AKI), the molecular …

Sepsis‐induced acute kidney injury (SI‐AKI) is common and associated with high mortality.
Survivors are at increased risk of chronic kidney disease. The precise mechanism …

Renal hypouricemia (RHUC) is a hereditary disease that presents with increased renal urate
clearance and hypouricemia due to genetic mutations in the urate transporter URAT1 or …

Acute kidney injury (AKI) is a common and devastating pathologic condition, associated with
considerable high morbidity and mortality. Although significant breakthroughs have been …

The innate immune system plays an important role as a first response to tissue injury. This
first response is carried out via germline-encoded receptors. Toll-like receptors (TLRs) are …

Introduction Acute kidney injury (AKI) is a common and feared complication of sepsis. The
pathogenesis of sepsis-induced AKI is largely unknown, and therapeutic interventions are …