The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in
neuroinflammatory disorders, but the ability to effectively target these receptors in models of …

Aims Neuronal hypersensitisation due to adenosine triphosphate‐dependent P2X3 receptor
signalling plays a significant role in several disorders including chronic cough and …

The G protein-coupled P2Y12 receptor (P2Y12R) was cloned in platelets and found to play
a key role in maintaining platelet function in hemostasis and thrombosis, and these effects …

Vesicular nucleotide transporter (VNUT) is the last identified member of the SLC17 organic
anion transporter family, which plays a central role in vesicular storage in ATP-secreting …

The occurrence and development of tumors is a multi-factor, multi-step, multi-gene
pathological process, and its treatment has been the most difficult problem in the field of …

Mechanical allodynia can be evoked by punctate pressure contact with the skin (punctate
mechanical allodynia) and dynamic contact stimulation induced by gentle touching of the …

The permeability of large cations through the P2X pore has remained arguably the most
controversial and complicated topic in P2X-related research, with the emergence of …

Trigeminal neuralgia (TN) is a type of severe paroxysmal neuropathic pain commonly
triggered by mild mechanical stimulation in the orofacial area. Piezo2, a mechanically gated …

In the nervous system, ATP is co-stored in vesicles with classical transmitters and released
in a regulated manner. ATP from the intracellular compartment can also exit the cell through …

Diabetic neuropathic pain (DNP), one of the early symptoms of diabetic neuropathy, relates
to metabolic disorders induced by high blood glucose, neurotrophic vascular ischemia and …