Methylene blue (MB) is a cationic thiazine dye, widely used as a biological stain and
chemical indicator. Growing evidence have revealed that MB functions to restore abnormal …

Background Neuropathic pain (NP) caused by the injury or dysfunction of the nervous
system is a chronic pain state accompanied by hyperalgesia, and the available clinical …

Chronic pain affects approximately one-fifth of people worldwide and reduces quality of life
and in some cases, working ability. Ion channels expressed along nociceptive pathways …

Highlights•P2X7 receptor is important in insulin secretion and responses of insulin sensitive
tissues.•Microvascular complications of diabetes involve P2X7 receptor.•Analysis of tissue …

In recent decades, diabetes mellitus (DM) has become a major global health problem owing
to its high prevalence and increased incidence of diabetes-associated complications …

The family of ligand-gated ion channels known as P2X receptors were discovered several
decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research …

Many factors are involved in the development of cancer pain, which is a serious
complication of cancer and affects the quality of life of patients, Normally, drugs are used to …

Neuropathic pain is a common clinical symptom of various diseases, and it seriously affects
the physical and mental health of patients. Owing to the complex pathological mechanism of …

Background Pain is a rapid response mechanism that compels organisms to retreat from the
harmful stimuli and triggers a repair response. Nonetheless, when pain persists for extended …

Artificial intelligence (AI) has been recognized as a powerful technique that can accelerate
drug discovery during the hit compound identification step. However, most simple deep …