Peripheral stimuli are transduced by specific receptors expressed by sensory neurons and
are further processed in the dorsal horn of spinal cord before to be transmitted to the brain …

Nicotinic acetylcholine receptors (nAChRs) are pharmacological targets for the treatment of
neuropathic pain, and the α6β4 subtype has been identified as particularly promising. Rat …

Aim: This study investigated whether the neuronal P2X3 receptor in rat dorsal root ganglia
(DRG) mediated the effects of hesperidin on neuropathic pain. Materials and methods: The …

Abstract Background and Objectives The potent, selective P2X3 receptor antagonist
eliapixant (BAY 1817080) is under development for conditions characterized by neuronal …

Peripheral inflammation and nerve injury usually accompany each other. However, whether
inflammatory and neuropathic pain share similar mechanisms at all stages is unknown …

The insular cortex (IC) is known to process pain information. However, analgesic effects of
glial inhibition in the IC have not yet been explored. The aim of this study was to investigate …

Painful diabetic neuropathy (PDN) is a diabetes mellitus complication. Unfortunately, the
mechanisms underlying PDN are still poorly understood. Adenosine triphosphate (ATP) …

Purpose To observe the effects of electroacupuncture on ocular surface neuralgia and the
P2X3R-PKC signaling pathway in guinea pigs with dry eye. Methods A dry eye guinea pig …

Diabetes mellitus is one of the most widespread metabolic diseases in the world, and
diabetic foot ulcer (DFU), as one of its chronic complications, not only causes a large amount …

The zebrafish has been considered an ideal model for studies of complex behaviors since
its behavioral repertoire is well described. Therefore, this study evaluated the perceived pain …