Bioactive aurones, indanones, and other hemiindigoid scaffolds: medicinal chemistry and photopharmacology perspectives
LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …
Recent developments in biological activities of indanones
Indanone is one of the privileged structures in medicinal chemistry and it's commonly
associated with various pharmacologically active compounds. The indanone moiety is found …
associated with various pharmacologically active compounds. The indanone moiety is found …
Medicinal chemistry of indane and its analogues: A mini review
Abstract 'Indane′ and its analogues indene, 1‐indenone, and 1, 3‐indandione present an
attractive biological profile for the rational development of therapeutic molecules. The …
attractive biological profile for the rational development of therapeutic molecules. The …
[HTML][HTML] The recent development of donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's agents: highlights from 2010 to 2020
Dementia is a term used to define different brain disorders that affect memory, thinking,
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
[HTML][HTML] Synthesis of new benzothiazole acylhydrazones as anticancer agents
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of
the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal …
the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal …
Design, synthesis and molecular docking and ADME studies of novel hydrazone derivatives for AChE inhibitory, BBB permeability and antioxidant effects
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that is
characterized by memory and cognitive impairments that predominantly affects the elderly …
characterized by memory and cognitive impairments that predominantly affects the elderly …
Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their
inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles …
inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles …
ABCpred: a webserver for the discovery of acetyl-and butyryl-cholinesterase inhibitors
AA Malik, SC Ojha, N Schaduangrat… - Molecular Diversity, 2022 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia and is associated
with a decline in cognitive function and language ability. The deficiency of the cholinergic …
with a decline in cognitive function and language ability. The deficiency of the cholinergic …
Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …