Bioactive aurones, indanones, and other hemiindigoid scaffolds: medicinal chemistry and photopharmacology perspectives

LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Recent developments in biological activities of indanones

SA Patil, R Patil, SA Patil - European journal of medicinal chemistry, 2017 - Elsevier
Indanone is one of the privileged structures in medicinal chemistry and it's commonly
associated with various pharmacologically active compounds. The indanone moiety is found …

Medicinal chemistry of indane and its analogues: A mini review

P Prasher, M Sharma - ChemistrySelect, 2021 - Wiley Online Library
Abstract 'Indane′ and its analogues indene, 1‐indenone, and 1, 3‐indandione present an
attractive biological profile for the rational development of therapeutic molecules. The …

[HTML][HTML] The recent development of donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's agents: highlights from 2010 to 2020

RT Kareem, F Abedinifar, EA Mahmood, AG Ebadi… - RSC …, 2021 - pubs.rsc.org
Dementia is a term used to define different brain disorders that affect memory, thinking,
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …

Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors

F Tok, B Koçyiğit-Kaymakçıoğlu, BN Sağlık, S Levent… - Bioorganic …, 2019 - Elsevier
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …

[HTML][HTML] Synthesis of new benzothiazole acylhydrazones as anticancer agents

D Osmaniye, S Levent, AB Karaduman, S Ilgın… - Molecules, 2018 - mdpi.com
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of
the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal …

Design, synthesis and molecular docking and ADME studies of novel hydrazone derivatives for AChE inhibitory, BBB permeability and antioxidant effects

D Osmaniye, I Ahmad, BN Sağlık, S Levent… - Journal of …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that is
characterized by memory and cognitive impairments that predominantly affects the elderly …

Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives

BN Sağlık, UA Cevik, D Osmaniye, S Levent… - Bioorganic …, 2019 - Elsevier
New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their
inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles …

ABCpred: a webserver for the discovery of acetyl-and butyryl-cholinesterase inhibitors

AA Malik, SC Ojha, N Schaduangrat… - Molecular Diversity, 2022 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia and is associated
with a decline in cognitive function and language ability. The deficiency of the cholinergic …

Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents

BN Sağlık, S Levent, D Osmaniye, AE Evren… - ACS …, 2022 - ACS Publications
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …