Biological activity of ionic liquids and their application in pharmaceutics and medicine
KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …
modern science. Because of their highly tunable nature and exceptional properties, ionic …
Getting across the cell membrane: an overview for small molecules, peptides, and proteins
NJ Yang, MJ Hinner - Site-Specific Protein Labeling: Methods and …, 2015 - Springer
The ability to efficiently access cytosolic proteins is desired in both biological research and
medicine. However, targeting intracellular proteins is often challenging, because to reach …
medicine. However, targeting intracellular proteins is often challenging, because to reach …
Spatiotemporal manipulation metal–organic frameworks as oral drug delivery systems for precision medicine
Z Wang, J Chen, R Gao, L Jiang, G Zhang… - Coordination Chemistry …, 2024 - Elsevier
Oral drug administration is the preferred method for delivering medications due to its safety,
ease of ingestion, high patient compliance, absence of pain, and adaptability to a wide …
ease of ingestion, high patient compliance, absence of pain, and adaptability to a wide …
Bile acid transporter-mediated oral drug delivery
Bile acids are synthesized in the liver, stored in the gallbladder, and secreted into the
duodenum at meals. Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+ …
duodenum at meals. Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+ …
[HTML][HTML] Transporter-mediated drug delivery
G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
[HTML][HTML] Prodrugs for improved drug delivery: lessons learned from recently developed and marketed products
Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …
parent drug in the body. In the past, prodrugs were used as a last option; however …
[HTML][HTML] Antibacterial prodrugs to overcome bacterial resistance
B Jubeh, Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Bacterial resistance to present antibiotics is emerging at a high pace that makes the
development of new treatments a must. At the same time, the development of novel …
development of new treatments a must. At the same time, the development of novel …
An imine based COF as a smart carrier for targeted drug delivery: From synthesis to computational studies
L Akyuz - Microporous and Mesoporous Materials, 2020 - Elsevier
Abstract Covalent Organic Frameworks (COFs) are a remarkable class of porous solids and
they are defined as organic polymeric materials having a large surface area and chemical …
they are defined as organic polymeric materials having a large surface area and chemical …
Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport
Challenges to effective delivery of drugs following oral administration has attracted growing
interest over recent decades. Small molecule drugs (< 1000 Da) are generally absorbed …
interest over recent decades. Small molecule drugs (< 1000 Da) are generally absorbed …
Prodrugs Design Based on Inter‐and Intramolecular Chemical Processes
R Karaman - Chemical biology & drug design, 2013 - Wiley Online Library
This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …
with the emphasis on the modern approaches to prodrug design. The chemical approach …