Publisher Summary The chapter describes the understanding of the physics and physical
chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The …

The thermodynamic activity of proteins in solution is substantially altered by the addition of
unreactive or 'inert'macromolecules occupying more than a few percent of total solution …

When the clinical manifestations of 272 patients with sickle cell anemia are compared with
their level of fetal hemoglobin (HbF), the results suggest that there may be a threshold above …

Previous studies have demonstrated that sickle cell disease (SCD) can be corrected in
mouse models by transduction of hematopoietic stem cells with lentiviral vectors containing …

When transgenic mice that expressed human sickle hemoglobin were mated with mice
having knockout mutations of the mouse α-and β-globin genes, animals were produced that …

Patients with homozygous sickle-cell disease may be homozygous for alpha-thalassemia 2
(α–/α–), may be heterozygous for alpha-thalassemia 2 (α–/αα), or may have a normal alpha …

Sickle cell disease (SCD), caused by a mutation in the β-globin gene HBB, is widely
distributed in malaria endemic regions. Cardiopulmonary complications are major causes of …

Static and dynamic deformabilities of erythrocytes are important determinants of
microcirculatory blood flow. To determine the influence of increased cellular hemoglobin …

We examined the extent to which the intracellular polymerization of sickle hemoglobin (HbS)
can account for the severity of anemia and of vaso-occlusive manifestations in the various …

Protein representation learning is a challenging task that aims to capture the structure and
function of proteins from their amino acid sequences. Previous methods largely ignored the …