ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …

The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that
constitutes one of four members of the erbB family of tyrosine kinase receptors. Binding of …

There are more than half a million incident cases of squamous-cell carcinoma of the head
and neck worldwide each year, primarily affecting the oropharynx, oral cavity, hypopharynx …

Squamous cell carcinoma of the head and neck (HNSCC) is a relatively common human
cancer characterized by high morbidity, high mortality, and few therapeutic options outside …

Purpose To evaluate the efficacy and safety of the epidermal growth factor receptor–directed
monoclonal antibody cetuximab administered as a single agent in patients with recurrent …

Purpose Therapy of recurrent/metastatic squamous cell carcinoma of the head and neck
results in median progression-free survival (PFS) of 2 months. These cancers are rich in …

Purpose Erlotinib is a highly specific epidermal growth factor receptor (HER1/EGFR)
tyrosine kinase inhibitor. This phase II study of erlotinib in patients with HER1/EGFR …

Purpose To determine the efficacy and safety profiles of erlotinib in patients with advanced
recurrent and/or metastatic squamous cell cancer of the head and neck (HNSCC). Patients …

While a large proportion of patients presenting with stage I and II squamous cell carcinoma
of the head and neck (SCCHN) will remain disease free after single modality treatment, the …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family
that is abnormally activated in many epithelial tumors. Several mechanisms lead to the …