The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

[HTML][HTML] Quorum sensing: A less known mode of communication among fungi

SA Padder, R Prasad, AH Shah - Microbiological research, 2018 - Elsevier
Quorum sensing (QS), a density-dependent signaling mechanism of microbial cells, involves
an exchange and sense of low molecular weight signaling compounds called autoinducers …

[HTML][HTML] Infection of fungi and bacteria in brain tissue from elderly persons and patients with Alzheimer's disease

R Alonso, D Pisa, AM Fernández-Fernández… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. The etiology of
this disease remains a matter of intensive research in many laboratories. We have advanced …

[HTML][HTML] Time to conquer fungal infectious diseases: employing nanoparticles as powerful and versatile antifungal nanosystems against a wide variety of fungal …

A Jangjou, Z Zareshahrabadi, M Abbasi… - Sustainability, 2022 - mdpi.com
The development of novel antifungal agents and, in particular, the widespread use of these
medications over the course of the past two decades, has had a significant impact on the …

[HTML][HTML] Fungal pigments and their roles associated with human health

L Lin, J Xu - Journal of Fungi, 2020 - mdpi.com
Fungi can produce myriad secondary metabolites, including pigments. Some of these
pigments play a positive role in human welfare while others are detrimental. This paper …

Emergence and evolution of virulence in human pathogenic fungi

S Siscar-Lewin, B Hube, S Brunke - Trends in microbiology, 2022 - cell.com
One billion people worldwide are affected by fungal pathogens, of which 1.6 million
succumb to fungal infections per year. This review discusses the emergence and evolution …

[HTML][HTML] Checkpoint inhibitors as immunotherapy for fungal infections: Promises, challenges, and unanswered questions

S Wurster, SS Watowich, DP Kontoyiannis - Frontiers in immunology, 2022 - frontiersin.org
Opportunistic fungal infections have high mortality in patients with severe immune
dysfunction. Growing evidence suggests that the immune environment of invasive fungal …

[HTML][HTML] Immune intervention in sepsis

J Chen, H Wei - Frontiers in Pharmacology, 2021 - frontiersin.org
Sepsis is a host immune disorder induced by infection. It can lead to multiple organ
dysfunction syndrome (MODS), which has high morbidity and mortality. There has been …

[HTML][HTML] Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion

A Pradhan, GM Avelar, JM Bain, D Childers… - Nature …, 2019 - nature.com
To colonise their host, pathogens must counter local environmental and immunological
challenges. Here, we reveal that the fungal pathogen Candida albicans exploits diverse host …

PAMPs of the fungal cell wall and mammalian PRRs

R Hatinguais, JA Willment, GD Brown - The Fungal Cell Wall: An Armour …, 2020 - Springer
Fungi are opportunistic pathogens that infect immunocompromised patients and are
responsible for an estimated 1.5 million deaths every year. The antifungal innate immune …