Neuromodulation is a field of science, medicine, and bioengineering that encompasses
implantable and non-implantable technologies for the purpose of improving quality of life …

Introduction Implanted neurostimulation devices are gaining traction as therapeutic options
for people with certain forms of drug-resistant focal epilepsy. Some of these devices enable …

The responsive neurostimulator (RNS®, NeuroPace Inc.) has been available clinically since
2013 for the treatment of medically refractory partial epilepsy. Using intracranial electrodes …

Responsive neurostimulation is a promising treatment for drug-resistant focal epilepsy;
however, clinical outcomes are highly variable across individuals. The therapeutic …

Neuromorphic systems take inspiration from the principles of biological information
processing to form hardware platforms that enable the large-scale implementation of neural …

Nearly 1% of the global population suffers from epilepsy. Drug‐resistant epilepsy (DRE)
affects one‐third of epileptic patients who are unable to treat their condition with existing …

Key points On‐demand optogenetic inhibition of glutamatergic neurons in the fastigial
nucleus of the cerebellum does not alter hippocampal seizures in a mouse model of …

Single neuron actions and interactions are the sine qua non of brain function, and nearly all
diseases and injuries of the CNS trace their clinical sequelae to neuronal dysfunction or …

Objective Epilepsy is characterized by spontaneous seizures that recur at unexpected times.
Nonetheless, using years‐long electroencephalographic (EEG) recordings, we previously …

In approximately 30% of patients with epilepsy, seizures are refractory to medical therapy,
leading to significant morbidity and increased mortality. Substantial evidence has …