Chronic pain is characterized by discrete pain episodes of unpredictable frequency and
duration. This hinders the study of pain mechanisms and contributes to the use of …

To date, the unpredictability of seizures remains a source of suffering for people with
epilepsy, motivating decades of research into methods to forecast seizures. Originally, only …

Head-to-head comparison of treatment modalities such as VNS, DBS and RNS across
different epileptic syndromes are required to decide which treatment modality is the most …

Recent review papers have investigated seizure prediction, creating the possibility of
preempting epileptic seizures. Correct seizure prediction can significantly improve the …

Brain stimulation (BStim) encompasses multiple modalities (eg, deep brain stimulation,
responsive neurostimulation) that utilize electrodes implanted in deep brain structures to …

Introduction: There are over twenty anti-seizure medications and anti-seizure devices
available commercially in the United States. The multitude of treatment options for seizures …

Epilepsy surgery has seen numerous technological advances in both diagnostic and
therapeutic procedures in recent years. This has increased the number of patients who may …

Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …

In this article, we explore how deep brain stimulation (DBS) devices designed to “close the
loop”—to automatically adjust stimulation levels based on computational algorithms—may …

Background: Despite the wide availability of novel anti-seizure medications (ASMs), 30% of
patients with epilepsy retain persistent seizures with a significant burden in comorbidity and …